Bone age and chronological age
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9.0☒.4 p < 0.001).ĭA in children may be altered by cancer disease.ĭissertação (mestrado)-Universidade de Brasília, Faculdade de Ciências da Saúde, 2009. The DA of cancer patients having teeth with short roots was significantly greater than that of the cancer survivors without this anomaly (12.8☓.2 vs. All four patients with HP suffered from FAP, and three of them had documented adenomatous polyposis coli (APC) genes mutation. Among all cancer patients, only children with familial adenomatous polyposis (FAP)-associated hepatoblastoma (HP) demonstrated delayed DA, with regard to both other cancer survivors (p=0.01) and healthy patients (p=0.03). The greatest difference was observed among patients with brain tumor: delta (DA-CA) was 2.2☑.1 years. The DA of cancer survivors was accelerated by almost 1 year compared to their CA (9.9☓.1 vs. Dental age (DA) was estimated with Demirjian's scale and delta age, i.e., DA-chronological age (CA), was used to compare groups. The control group consisted of 177 panoramic radiographs of age- and sex-matched healthy individuals. The mean duration of anticancer therapy was 16.8 months (range, 1 to 47 months), and 4.6 years (range, 8 to 123 months) had passed since the termination of disease. The study aimed to assess the differences in dental maturation between childhood cancer survivors and healthy children.įifty-nine cancer patients including 16 (27.1%) girls and 43 (72.8%) boys, aged between 4 and 16 years, underwent dental and radiographic examinations. Therefore, the complete characterization of the main methods and procedure available and particularly of all their advantages and disadvantages need to be known in order to properly utilized this information for all its medical and non-medical main fields of application. As well several differences can be characterized according to the numerous standardized methods developed over the past decades. Bone age may be affected by several factors, including gender, nutrition, as well as metabolic, genetic, and social factors and either acute and chronic pathologies especially hormone alteration. This information, associated to the characterization of the shape and changes of bone components configuration, represent an important factor of the biological maturation process of a subject. In fact, the images obtained by hand and wrist X-ray reflect the maturity of different types of bones of the skeletal segment evaluated. Although several bones have been studied to better define bone age, the hand and wrist X-rays are the most used images. It is defined by the age expressed in years that corresponds to the level of maturation of bones. A large prospective study is warranted to better define our observations and to determine their impact on dental and orthodontic management.īone age represents a common index utilized in pediatric radiology and endocrinology departments worldwide for the definition of skeletal maturity for medical and non-medical purpose. Abnormal BA, abnormal DA, and discrepancy between BA and DA are not statistically significantly associated with investigated patient or treatment factors.ĭA may be altered in 43.1% of patients treated for ALL. Median CA at diagnosis was 4.5 years (range: 0.1-11.0 years) time to study was 4.1 years (range: 0.3-11.4 years). The cohort was divided into three categories based on age at diagnosis ( 9 years). We recorded patient demographics, therapeutic protocol, CA, DA, and BA. We retrospectively reviewed hand-wrist and panoramic radiographs of patients treated on contemporary single institution protocols for ALL between 19. The objective of this study was to compare bone age (BA) and dental age (DA) to chronological age (CA) in childhood ALL survivors. There is little information about oncotherapy-related dental development in childhood acute lymphoblastic leukaemia (ALL).